The Science Behind Hangover Ace

Hangxiety has become a buzzword that describes the uneasy feeling that often accompanies heavy alcohol use, but what does it really mean?

  Drinking alcohol dumps a flood of dopamine into the pleasure center of the brain. The feel-good chemical swirls through your head, but the rush only lasts for a short while. When dopamine levels dip back down, feelings of anxiety rebound. Researchers think that may be one reason why people who experience hangxiety, especially those who are extremely shy, may have a higher risk of experiencing hangxiety. 

Heavy drinking produces physiological changes in the brain. When you’re drinking, there’s an influx of the GABA (gamma aminobutyric acid), which causes you to feel relaxed and calm. When you stop drinking, you have withdrawal symptoms. Your body gets used to that crutch to feel calm. Take it away and anxiety often follows. Add interrupted sleep to the mix, which often happens when people drink to excess, and feelings of depression and anxiety can get even worse.

So what’s a good way to drink responsibly and avoid negative side effects?

The answer involves providing your body with nutrients that promote rapid alcohol detoxification. Hangover Ace contains the right combination of such nutrients. Learn more about these nutrients, and why they help, below.

The Science Behind the Ingredients
Synephrine HCl

Synephrine HCl is an active component in some citrus extracts (e.g., bitter orange extract). It helps enhance energy, mental focus, and physical performance [3]. Synephrine HCl is described as a stimulant that has a similar structure to ephedrine, but Synephrine HCl is not linked to the heart-related side effects that ephedrine causes [3, 4]. In addition to its stimulating properties, Synephrine HCl supplementation promotes the breakdown of fat that the body can use for energy and enhancing the transportation of nutrients (e.g., carbohydrates, electrolytes, vitamins) [3]. These help lessen the occurrence of issues such as fatigue, dehydration, and reduced mental performance.

Caffeine Anhydrous and L-Theanine

According to research, combining Caffeine Anhydrous and L-Theanine boosts mental performance, improves mood, and heightens mental energy [5]. Caffeine is well-known for its mood-boosting, stimulating, and energizing properties, while L-Theanine is an amino acid that has stress-reducing, calming, and relaxing properties, as well as powerful antioxidant activity that helps protect your liver from the negative effects of alcohol [6, 7]. In addition, L-Theanine also appears to lessen the negative effects of caffeine that include headaches, nervousness, insomnia, etc., Therefore, these ingredients work together well to support a healthy response to the use of alcohol. [8].

Green Tea Extract, N-Methytyramine, and Quercetin

Green tea extract targets issues related to the consumption of alcohol in a similar manner as L-Theanine. More specifically, green tea extract contains polyphenols which function as antioxidants that support detoxification and protect various cells (e.g., liver cells) from toxin damage [9]. However, green tea extract also contains epigallocatechin gallate (EGCG), which is a powerful substance that helps lessen fatigue, mood disturbances, and concentration problems by enhancing nutrient metabolism and boosting energy levels [9].


Quercetin is also a type of phenol with antioxidant properties that improve the breakdown of alcohol and reduce the accumulation of congeners, thereby promoting a healthier response to alcohol [10].

N-Methytyramine has a similar function as EGCG because it improves energy levels by increasing the digestion and absorption of nutrients [11]. This improves the body's response to alcohol by ensuring that essential nutrients are still circulating while the liver works to remove alcohol from the body.

Mental Performance Enhancers

Several mental performance enhancers, such as Dimethylaminoethanol (DMAE) Bitartrate and Acetyl-L-Carnitine, can also be found in Hangover Ace. These types of substances have energy-boosting, blood circulation-enhancing, and brain cell protecting properties [12, 13]. Furthermore, this particular combination ensures that important nutrients the brain needs, including oxygen, are consistently circulated to brain cells that influence mental performance. Decreased nutrient absorption and transportation is one of the reasons people experience mental performance issues after drinking, but the ingredients in Hangover Ace help maintain optimal levels of essential nutrients the brain needs to remain in top form.

Blend of Detoxification

The combination of ingredients in Hangover Ace, such as N-acetyl-l-cysteine, B vitamins (e.g., B1, B2, B6, and B12), and magnesium glycinate, promote the detoxification of alcohol and other toxic substances (e.g., congeners) from the liver [14]. The faster alcohol particles and congers are removed from the body, the less likely a person is to experience negative symptoms.

Vitamins B6 and B12, in particular, are essential vitamins that heighten energy levels, target substance-related toxicity, and even help improve health problems that are linked to nonalcoholic fatty liver disease [15, 16]. This means that in addition to promoting the detoxification of alcohol and congeners, B vitamins also help protect the liver, which is the main organ that processes alcohol. Furthermore, the combination of B vitamins and magnesium glycinate enhance the activity of enzymes that play a role in detoxification [15, 16].

The carefully chosen ingredients in Hangover Ace not only target negatives associated with drinking, but also provide enhanced protection for the liver; an added benefit for people who regularly consume alcohol.

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Anxiety is a common feeling when people drink too much. Elizabeth Bulat, M.D., a substance abuse specialist at Henry Ford Health System.