The Science Behind Hangover Ace

A hangover from drinking alcohol is typically due to a combination of unpleasant symptoms that include:
Muscle pain
A rapid heartbeat
Sleep disturbances
Poor concentration
Tremors (Shakiness)
Fatigue and weakness
A dry mouth and excessive thirst
Nausea, vomiting, or stomach pain
An increased sensitivity to sounds and light
Dizziness (e.g., feeling as if the room spinning)
Mood disturbances (e.g., anxiety, irritability, depression)

These symptoms usually are experienced upon waking up after a night of heavy drinking, and for some people may last about 24 hours. The symptoms of hangover are linked to a number of factors. For instance, drinking alcohol increases urine production and frequent urination can lead to dehydration, which can subsequently cause dizziness, thirst, and poor concentration, among other issues [1].

In addition, drinking large amounts of alcohol speeds up metabolism due to the fact that the liver works harder to break down the alcohol and remove it from the body [1]. Unfortunately, this disrupts the liver’s ability to break down carbohydrates and release nutrients such as glucose (sugar). When this happens, your body is unable to properly regulate blood sugar or energy production and symptoms such as fatigue, tremors, weakness, and mood disturbances may develop.

Furthermore, alcoholic drinks contain congeners, which are substances that are produced when certain alcoholic beverages are being manufactured. Specific types of congeners give alcoholic drinks a unique flavor, but high levels of congeners can cause or worsen a hangover [2]. For some people, having just one strong drink may lead to an unpleasant hangover the next morning, especially if the drink contained significant amounts of congeners.

So what’s a good way to drink responsibly and avoid a hangover?

The answer involves providing your body with nutrients that promote rapid alcohol detoxification. Hangover Ace contains the right combination of such nutrients. Learn more about these nutrients, and why they work, below.

The Science Behind the Ingredients
Synephrine HCl

Synephrine HCl is an active component in some citrus extracts (e.g., bitter orange extract). It helps enhance energy, mental focus, and physical performance [3]. Synephrine HCl is described as a stimulant that has a similar structure to ephedrine, but Synephrine HCl is not linked to the heart-related side effects that ephedrine causes [3, 4]. In addition to its stimulating properties, Synephrine HCl supplementation counteracts a hangover by promoting the breakdown of fat that the body can use for energy and enhancing the transportation of nutrients (e.g., carbohydrates, electrolytes, vitamins) [3]. These factors help prevent hangover symptoms such as fatigue, dehydration, and reduced mental performance.

Caffeine Anhydrous and L-Theanine

According to research, combining Caffeine Anhydrous and L-Theanine boosts mental performance, improves mood, and heightens mental energy [5]. Caffeine is well-known for its mood-boosting, stimulating, and energizing properties, while L-Theanine is an amino acid that has stress-reducing, calming, and relaxing effects, as well as powerful antioxidant activity that helps protect your liver from the negative effects of alcohol [6, 7]. In addition, L-Theanine also appears to lessen the negative effects of caffeine that include headaches, nervousness, insomnia, etc., which makes the blend of these two ingredients especially important at preventing a hangover [8].

Green Tea Extract, N-Methytyramine, and Quercetin

Green tea extract targets hangover symptoms in a similar manner as L-Theanine. More specifically, green tea extract contains polyphenols which function as antioxidants that support detoxification and protect various cells (e.g., liver cells) from toxin damage [9]. However, green tea extract also contains epigallocatechin gallate (EGCG), which is a powerful substance that helps counteract hangover-induced fatigue, mood disturbances, and concentration problems by enhancing nutrient metabolism and boosting energy levels [9].


Quercetin is also a type of phenol with antioxidant properties that improve the breakdown of alcohol and reduce the accumulation of congeners, thereby targeting hangover symptoms [10].

N-Methytyramine has a similar function as EGCG because it improves energy levels by increasing the digestion and absorption of nutrients [11]. This counteracts the effects of a hangover by ensuring that essential nutrients are still circulating while the liver works to remove alcohol from the body.

Mental Performance Enhancers

Several mental performance enhancers, such as Dimethylaminoethanol (DMAE) Bitartrate and Acetyl-L-Carnitine, can also be found in Hangover Ace. These types of substances have energy-boosting, blood circulation-enhancing, and brain cell protecting properties [12, 13]. Furthermore, this particular combination ensures that important nutrients the brain needs, including oxygen, are consistently circulated to brain cells that influence mental performance. Decreased nutrient absorption and transportation is one of the reasons people experience mental performance issues during a hangover, but the ingredients in Hangover Ace help maintain optimal levels of essential nutrients the brain needs to remain in top form.

Blend of Detoxification

The combination of ingredients in Hangover Ace, such as N-acetyl-l-cysteine, B vitamins (e.g., B1, B2, B6, and B12), and magnesium glycinate, promote the detoxification of alcohol and other toxic substances (e.g., congeners) from the liver [14]. The faster alcohol particles and congeners are removed from the body, the less likely a person is to experience a hangover.

Vitamins B6 and B12, in particular, are essential vitamins that heighten energy levels, target substance-related toxicity, and even help improve symptoms that are linked to nonalcoholic fatty liver disease [15, 16]. This means that in addition to promoting the detoxification of alcohol and congeners, B vitamins also help protect the liver, which is the main organ that processes alcohol. Furthermore, the combination of B vitamins and magnesium glycinate enhance the activity of enzymes that play a role in detoxification [15, 16].

The carefully chosen ingredients in Hangover Ace not only target hangover symptoms, but also provide enhanced protection for the liver; an added benefit for people who regularly consume alcohol.

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